Switching to INVEGA SUSTENNA® After 4th Dose of INVEGA TRINZA®

Dose Information

Graph Information

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Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA SUSTENNA®:

  • INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® (1-month paliperidone palmitate extended-release injectable suspension) has been established as adequate treatment for at least four months.
  • For switching from INVEGA TRINZA® to INVEGA SUSTENNA®, INVEGA SUSTENNA® should be started 3 months after the last INVEGA TRINZA® dose, using the equivalent 3.5-fold lower dose as shown in the table below.


If the Last Dose of INVEGA TRINZA® is: Initiate* INVEGA SUSTENNA® 3 Months Later at the Following Dose:
273 mg
78 mg
410 mg
117 mg
546 mg
156 mg
819 mg
234 mg
* The initiation dosing as described in the prescribing information for INVEGA SUSTENNA® is not required.
  • The cumulative paliperidone plasma level curve will reflect the plasma level contributions from the INVEGA TRINZA® treatment and INVEGA SUSTENNA® in this scenario.
  • INVEGA SUSTENNA® should then continue, dosed at monthly intervals.
  • Administration: For intramuscular injection only by a healthcare professional. Care should be taken to avoid inadvertent injection into a blood vessel.

INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

Educational Dose Illustrator for:
INVEGA SUSTENNA® (paliperidone palmitate)
INVEGA TRINZA® (paliperidone palmitate)

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:


  • the treatment of schizophrenia in adults
  • the treatment of schizoaffective disorder in adults as monotherapy and as an adjunct to mood stabilizers or antidepressants


  • the treatment of schizophrenia in patients after they have been adequately treated with INVEGA SUSTENNA® for at least four months.

This resource simulates the paliperidone plasma concentrations over time resulting from different dosing scenarios that are set forth in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. The Educational Dose Illustrator is intended to be used as a resource to foster a better understanding of, and educate healthcare professionals about, the dosing recommendations provided in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. It is intended for educational purposes only.

Because the simulated patient paliperidone plasma levels shown in the dosing scenarios are based upon aggregated pharmacokinetic information from clinical studies, the simulations may not be representative of individual patient response.

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