INVEGA TRINZA® Common Dosing and Administration Topics

Administration

Instructions for Preparation and Administration

Consistent with the INVEGA TRINZA® Prescribing Information:

  • Administer every 3 months
  • Shake syringe vigorously for at least 15 seconds

For intramuscular injection only. Do not administer by any other route.

Important:

  • INVEGA TRINZA® should be administered by a healthcare professional as a single injection. DO NOT divide dose into multiple injections.
  • INVEGA TRINZA® is intended for intramuscular use only. Inject slowly, deep into the muscle taking care to avoid injection into a blood vessel.
  • Read complete instructions prior to use.
  • Dosing
    • This medication should be administered once every 3 months.
  • Preparation
    • Peel off tab label from the syringe and place in patient record.
    • INVEGA TRINZA® requires longer and more vigorous shaking than INVEGA SUSTENNA® (1-month paliperidone palmitate extended-release injectable suspension). Shake the syringe vigorously, with the syringe tip pointing up, for at least 15 seconds within 5 minutes prior to administration (see Step 2).
  • Thin Wall Safety Needle Selection
    • Thin wall safety needles are designed to be used with INVEGA TRINZA®. Therefore, it is important to only use the needles provided in the INVEGA TRINZA® kit.

Dose Pack Contents

A side by side diagram, with a Prefilled Syringe on the left, and two Thin Wall Safety Needles on the right. There are annotations pointing to the Syringe Tip, Rubber Cap, and Luer Connection on the Prefilled Syringe. The first Thin Wall Safety Needle is labeled 22Gx1" with annotations pointing to the Needle Sheath and Needle Pouch. The second Thin Wall Safety Needle is labeled 22Gx1.5".

Step 1: Select needle

Needle selection is determined by injection area and patient weight.

Simple diagram of person with arrow pointing to deltoid titled `If administering a Deltoid injection`. Followed by, if patient weighs: Less than 90 kg pink hub 22Gx1". If patient weighs 90 kg or more, yellow hub 22Gx1.5". Simple diagram of person with arrow pointing to gluteal titled `If administering a Gluteal injection`. Followed by, if patient weighs: Less than 90 kg yellow hub 22Gx1.5". If patient weighs 90 kg or more, yellow hub 22Gx1.5".

Immediately discard the unused needle in an approved sharps container. Do not save for future use.

Step 2: Prepare for injection

Diagram of person shaking a syringe with it's tip pointing up, alongside text `15 SEC`

SHAKE VIGOROUSLY for at least 15 seconds

With the syringe tip pointing up, SHAKE VIGOROUSLY with a loose wrist for at least 15 seconds to ensure a homogeneous suspension.

NOTE: This medication requires longer and more vigorous shaking than the 1-month paliperidone palmitate extended-release injectable suspension.

Proceed to the next step immediately after shaking. If more than 5 minutes pass before injection, shake vigorously, with the syringe tip pointing up, again for at least 15 seconds to re-suspend the medication.

Check suspension

Diagram of person holding a syringe with emphasis on the viewing window.

After shaking the syringe for at least 15 seconds, check the liquid in the viewing window.

The suspension should appear uniform and milky white in color.

It is also normal to see small air bubbles.

Open needle pouch and remove cap

Diagram of person peeling the cover back on the needle pouch, and then holding the syringe upright and twisting and pulling the rubber cap to remove.

First, open needle pouch by peeling the cover back half way. Place on a clean surface. Then, holding the syringe upright, twist and pull the rubber cap to remove.

Grasp needle pouch

Diagram of person grasping the needle pouch

Fold back needle cover and plastic tray. Then, firmly grasp the needle sheath through the pouch, as shown.

Attach needle

Diagram of person holding the needle pouch and syringe, with the needle pointing up. The person is twisting the needle onto the syringe.

Hold the syringe pointing up. Attach the safety needle to the syringe using a gentle twisting motion to avoid needle hub cracks or damage. Always check for signs of damage or leakage prior to administration.

Remove needle sheath

Diagram of person holding the syringe with the needle pointing up, pulling the needle sheath straight off.

Pull the needle sheath away from the needle in a straight motion.

Do not twist the sheath, as this may loosen the needle from the syringe.

Remove air bubbles

Diagram of person holding the syringe with the needle pointing up, pressing the plunger rod upward as a drop of liquid comes out of the needle tip.

Hold the syringe upright and tap gently to make any air bubbles rise to the top.

Remove air by pressing the plunger rod upward carefully until a drop of liquid comes out of the needle tip.

Step 3: Inject

Inject dose

Diagram of injection location options.

Slowly inject the entire contents of the syringe intramuscularly, deep into the selected deltoid or gluteal muscle.

Do not administer by any other route.

Step 4: After injection

Secure needle

Diagram of person using their thumb to secure the needle in the safety device.

After the injection is complete, use your thumb or a flat surface to secure the needle in the safety device. The needle is secure when a "click" sound is heard.

Dispose properly

Diagram of needle being disposed of in a sharps container.

Dispose of the syringe and unused needle in an approved sharps container.

Thin wall safety needles are designed specifically for use with INVEGA TRINZA®. Unused needle should be discarded and not saved for future use.

Educational Dose Illustrator for:
INVEGA SUSTENNA® (paliperidone palmitate)
INVEGA TRINZA® (paliperidone palmitate)

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

  • the treatment of schizophrenia in adults
  • the treatment of schizoaffective disorder in adults as monotherapy and as an adjunct to mood stabilizers or antidepressants

INVEGA TRINZA® for:

  • the treatment of schizophrenia in patients after they have been adequately treated with INVEGA SUSTENNA® for at least four months.

This resource simulates the paliperidone plasma concentrations over time resulting from different dosing scenarios that are set forth in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. The Educational Dose Illustrator is intended to be used as a resource to foster a better understanding of, and educate healthcare professionals about, the dosing recommendations provided in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. It is intended for educational purposes only.

Because the simulated patient paliperidone plasma levels shown in the dosing scenarios are based upon aggregated pharmacokinetic information from clinical studies, the simulations may not be representative of individual patient response.

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This information is intended for healthcare providers in the United States only.

Last updated 10/23/2026

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