INVEGA SUSTENNA® Common Dosing and Administration Topics

Administration

Instructions for Preparation and Administration

Consistent with the INVEGA SUSTENNA® Prescribing Information:

Each injection must be administered only by a healthcare professional.

The kit contains a prefilled syringe and 2 safety needles (a 1 ½-inch 22 gauge needle and a 1-inch 23 gauge needle) for intramuscular injection.

Diagram of kit contents: a prefilled syringe and 2 safety needles (a 1 ½-inch 22 gauge needle and a 1-inch 23 gauge needle)

INVEGA SUSTENNA® is for single use only.

  • Shake the syringe vigorously for a minimum of 10 seconds to ensure a homogeneous suspension.
Diagram of person shaking a syringe with vigor.
  • Select the appropriate needle.
    • For DELTOID injection:
      • If the patient weighs less than 90 kg, use the 1-inch 23 gauge needle (needle with blue colored hub).
      • If the patient weighs 90 kg or more, use the 1 ½-inch 22 gauge needle (needle with gray colored hub).
    • For GLUTEAL injection:
      • Use the 1 ½-inch 22 gauge needle (needle with gray colored hub) regardless of patient's weight.
  • Hold the syringe with the tip cap pointing up. Remove the rubber tip cap with a gentle twisting motion.
Diagram of person twisting the syringe cap.
  • Peel the safety needle pouch half way open. Grasp the needle sheath using the plastic peel pouch. Hold the syringe pointing up. Attach the safety needle to the syringe using a gentle twisting motion to avoid needle hub cracks or damage. Always check for signs of damage or leaking prior to administration.
Diagram of person attaching the safety needle to the syringe.
  • Pull the needle sheath away from the needle with a straight pull. Do not twist the sheath as the needle may be loosened from the syringe.
Diagram of person holding the syringe with the needle pointing up, pulling the needle sheath straight off.
  • Bring the syringe with the attached needle in upright position to de-aerate. De-aerate the syringe by moving the plunger rod carefully forward.
Diagram of a person holding the syringe with the needle pointing up, pressing the plunger rod upward.
  • Inject the entire contents intramuscularly slowly, deep into the selected deltoid or gluteal muscle of the patient. Do not administer by any other route.
  • After the injection is complete, use either thumb or finger of one hand (h1, h2) or a flat surface (h3) to activate the needle protection system. The needle protection system is fully activated when a 'click' is heard. Discard the syringe with needle appropriately.
Diagram of person activating the needle protection system.

Educational Dose Illustrator for:
INVEGA SUSTENNA® (paliperidone palmitate)
INVEGA TRINZA® (paliperidone palmitate)

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

  • the treatment of schizophrenia in adults
  • the treatment of schizoaffective disorder in adults as monotherapy and as an adjunct to mood stabilizers or antidepressants

INVEGA TRINZA® for:

  • the treatment of schizophrenia in patients after they have been adequately treated with INVEGA SUSTENNA® for at least four months.

This resource simulates the paliperidone plasma concentrations over time resulting from different dosing scenarios that are set forth in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. The Educational Dose Illustrator is intended to be used as a resource to foster a better understanding of, and educate healthcare professionals about, the dosing recommendations provided in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. It is intended for educational purposes only.

Because the simulated patient paliperidone plasma levels shown in the dosing scenarios are based upon aggregated pharmacokinetic information from clinical studies, the simulations may not be representative of individual patient response.

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This information is intended for healthcare providers in the United States only.

Last updated 10/23/2026

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