Transition to INVEGA TRINZA®
| Dose Information |
|---|
Graph Information
Transitioning a Patient to INVEGA TRINZA®
Consistent with the INVEGA TRINZA® Prescribing Information:
- INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® has been established as adequate treatment for at least four months.
- In order to establish a consistent maintenance dose, it is recommended that the last two doses of INVEGA SUSTENNA® be the same dosage strength before starting INVEGA TRINZA®.
- Initiate INVEGA TRINZA® when the next INVEGA SUSTENNA® dose is scheduled with an INVEGA TRINZA® dose based on the previous INVEGA SUSTENNA® dose, using the equivalent 3.5-fold higher dose as shown in table below.
- INVEGA TRINZA® may be administered up to 7 days before or after the monthly time point of the next scheduled INVEGA SUSTENNA® dose.
INVEGA TRINZA® Doses for Adult Patients Adequately Treated with INVEGA SUSTENNA®
|
If the Last Dose of INVEGA SUSTENNA® is: |
Initiate INVEGA TRINZA® at the Following Dose: |
|
78 mg |
273 mg |
|
117 mg |
410 mg |
|
156 mg |
546 mg |
|
234 mg |
819 mg |
Conversion from the INVEGA SUSTENNA® 39 mg dose was not studied.
- INVEGA TRINZA® should be administered once every 3 months.
- If needed, dose adjustment can be made every 3 months in increments within the range of 273 mg to 819 mg based on individual patient tolerability and/or efficacy. Due to the long-acting nature of INVEGA TRINZA®, the patient’s response to an adjusted dose may not be apparent for several months.
- In a long-term placebo-controlled randomized-withdrawal trial, the percentages of patients with schizophrenia entering the double-blind phase on each of the INVEGA TRINZA® dose levels were 4% for 273 mg, 9% for 410 mg, 49% for 546 mg, and 38% for 819 mg.
- Administration: For intramuscular injection only by a healthcare professional. Care should be taken to avoid inadvertent injection into a blood vessel.
- Please see Dosage Adjustment in Renal Impairment in the INVEGA TRINZA® Prescribing Information for use in renal impairment.
INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]