From Oral INVEGA® ER to INVEGA SUSTENNA® – General Overview

Consistent with the INVEGA SUSTENNA® Prescribing Information:

• There are no systematically collected data to specifically address switching patients with schizophrenia or schizoaffective disorder from other antipsychotics to INVEGA SUSTENNA®, or concerning concomitant administration with other antipsychotics.
• Previous oral antipsychotics can be gradually discontinued at the time of initiation of treatment with INVEGA SUSTENNA®. Recommended initiation of INVEGA SUSTENNA® is with a dose of 234 mg followed by 156 mg one week later, both administered in the deltoid muscle. Patients previously stabilized on different doses of oral INVEGA® ER can attain similar paliperidone steady-state exposure during maintenance treatment with INVEGA SUSTENNA® monthly doses as depicted in the Table from the INVEGA SUSTENNA® Prescribing Information.

Table: Doses of INVEGA® and INVEGA SUSTENNA® needed to attain similar steady-state palliperidone exposure during maintenance treatment

Formulation	INVEGA® Exteneded-Release Tablet	INVEGA SUSTENNA® Injection
Dosing Frequency	Once Daily	Once every 4 weeks
Dose (mg)	12	234
	9	156
	6	117
	3	39-78

For illustrative displays of this dosing scenario, please click the link(s) below.

Switching from Oral INVEGA® ER for Schizophrenia