Dose Information

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INVEGA TRINZA® Managing a Missed Dose (4 months up to and including 9 months since the last injection)

Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA SUSTENNA®

• INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® has been established as adequate treatment for at least four months.
• Missing doses of INVEGA TRINZA® should be avoided.
• If 4 months up to and including 9 months have elapsed since the last injection of INVEGA TRINZA®, do NOT administer the next dose of INVEGA TRINZA®. Instead, use the re-initiation regimen shown in the table below.

Re-initiation Regimen After Missing 4 Months to 9 Months of INVEGA TRINZA®

If the Last Dose of INVEGA TRINZA® was: Administer INVEGA SUSTENNA®, two doses one week apart (into deltoid muscle) Then administer INVEGA TRINZA® (into deltoid or gluteal muscle) Day 1 Day 8 1 month after Day 8 273 mg 78 mg 78 mg 273 mg 410 mg 117 mg 117 mg 410 mg 546 mg 156 mg 156 mg 546 mg 819 mg 156 mg 156 mg 819 mg

See Instructions for Use for deltoid injection needle selection based on body weight.

• INVEGA TRINZA® should be administered every 3 months.
• Administration: For intramuscular injection only by a healthcare professional. Care should be taken to avoid inadvertent injection into a blood vessel.

INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]