2nd Injection 4 to 9 Months Since 1st Injection

  • Legend
    • initiation-dosing-symbol

      Initiation Doses

    • maintenace-dose-symbol

      Maintenance Doses

    • legend-pp1m-plasma-concentration

      Cumulative INVEGA SUSTENNA® Plasma Concentration

    • legend-pp3m-plasma-concentration

      Cumulative INVEGA TRINZA® Plasma Concentration

    • legend-er-plasma-concentration

      Cumulative Oral INVEGA® ER Plasma Concentration

    • legend-er-doses

      Daily Oral INVEGA® Doses

    • legend-rl-dose-symbol

      Cumulative RISPERDAL CONSTA® Plasma Concentration

    • median-plasma-concentration-symbol

      Median Plasma Concentration for Oral INVEGA® ER 6-12 mg/day

    • initiation-dosing-symbol

      Initiation Doses

    • maintenace-dose-symbol

      Maintenance Doses

    • legend-old-browser-paliperidone-palmitate-concentration

      Cumulative Paliperidone Palmitate Concentration

    • legend-er-doses

      Daily Oral INVEGA® ER Dose

    • legend-rl-dose-symbol-greyscale

      Cumulative RISPERDAL CONSTA® Plasma Concentration

    • Week 1 = Day 8

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Typical Paliperidone Plasma Concentration (ng/mL)
Typical Paliperidone Plasma Concentration (ng/mL)
Dose Information

Graph Information

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INVEGA TRINZA® Managing a Missed Dose (4 months up to and including 9 months since the last injection)

Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA SUSTENNA®

  • INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® has been established as adequate treatment for at least four months.
  • Missing doses of INVEGA TRINZA® should be avoided.
  • If 4 months up to and including 9 months have elapsed since the last injection of INVEGA TRINZA®, do NOT administer the next dose of INVEGA TRINZA®. Instead, use the re-initiation regimen shown in the table below.

Re-initiation Regimen After Missing 4 Months to 9 Months of INVEGA TRINZA®

If the Last Dose of INVEGA TRINZA® was:

Administer INVEGA SUSTENNA®, two doses one week apart (into deltoid muscle)

Then administer INVEGA TRINZA® (into deltoid or gluteal muscle)

Day 1

Day 8

1 month after Day 8

273 mg

78 mg

78 mg

273 mg

410 mg

117 mg

117 mg

410 mg

546 mg

156 mg

156 mg

546 mg

819 mg

156 mg

156 mg

819 mg

See Instructions for Use for deltoid injection needle selection based on body weight.

  • INVEGA TRINZA® should be administered every 3 months.
  • Administration: For intramuscular injection only by a healthcare professional. Care should be taken to avoid inadvertent injection into a blood vessel.

INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

Educational Dose Illustrator for:
INVEGA SUSTENNA® (paliperidone palmitate)
INVEGA TRINZA® (paliperidone palmitate)

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

  • the treatment of schizophrenia in adults
  • the treatment of schizoaffective disorder in adults as monotherapy and as an adjunct to mood stabilizers or antidepressants

INVEGA TRINZA® for:

  • the treatment of schizophrenia in patients after they have been adequately treated with INVEGA SUSTENNA® for at least four months.

This resource simulates the paliperidone plasma concentrations over time resulting from different dosing scenarios that are set forth in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. The Educational Dose Illustrator is intended to be used as a resource to foster a better understanding of, and educate healthcare professionals about, the dosing recommendations provided in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. It is intended for educational purposes only.

Because the simulated patient paliperidone plasma levels shown in the dosing scenarios are based upon aggregated pharmacokinetic information from clinical studies, the simulations may not be representative of individual patient response.

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