4th Injection 37 Weeks Since 3rd Injection

Dose Information

Graph Information

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INVEGA TRINZA® Managing a Missed Dose (>9 months since the last injection)

Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA SUSTENNA®:

  • INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® has been established as adequate treatment for at least four months.
  • Missing doses of INVEGA TRINZA® should be avoided.
  • If more than 9 months have elapsed since the last injection of INVEGA TRINZA®, re-initiate treatment with INVEGA SUSTENNA® as described in the prescribing information for INVEGA SUSTENNA® (234 mg on day 1 followed by 156 mg on day 8, both administered in the deltoid muscle). Monthly INVEGA SUSTENNA® maintenance doses can be administered in either the deltoid or gluteal muscle.
  • INVEGA TRINZA® can then be resumed after the patient has been adequately treated with INVEGA SUSTENNA® for at least 4 months.
  • INVEGA TRINZA® should be administered every 3 months.
  • Administration: For intramuscular injection only by a healthcare professional. Care should be taken to avoid inadvertent injection into a blood vessel.

INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

Educational Dose Illustrator for:
INVEGA SUSTENNA® (paliperidone palmitate)
INVEGA TRINZA® (paliperidone palmitate)

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:


  • the treatment of schizophrenia in adults
  • the treatment of schizoaffective disorder in adults as monotherapy and as an adjunct to mood stabilizers or antidepressants


  • the treatment of schizophrenia in patients after they have been adequately treated with INVEGA SUSTENNA® for at least four months.

This resource simulates the paliperidone plasma concentrations over time resulting from different dosing scenarios that are set forth in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. The Educational Dose Illustrator is intended to be used as a resource to foster a better understanding of, and educate healthcare professionals about, the dosing recommendations provided in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. It is intended for educational purposes only.

Because the simulated patient paliperidone plasma levels shown in the dosing scenarios are based upon aggregated pharmacokinetic information from clinical studies, the simulations may not be representative of individual patient response.

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