Single Dose Curve View
| Dose Information |
|---|
Graph Information
INVEGA TRINZA® Single-Dose Curves
The Single Dose Curve View represents the paliperidone plasma concentration of INVEGA TRINZA® when administered in either the deltoid or gluteal muscle following at least five months of INVEGA SUSTENNA® treatment (two initiation doses and four maintenance doses).
Consistent with the INVEGA TRINZA® Prescribing Information:
- INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® has been established as adequate treatment for at least four months.
- In order to establish a consistent maintenance dose, it is recommended that the last two doses of INVEGA SUSTENNA® be the same dosage strength before starting INVEGA TRINZA®.
- Initiate INVEGA TRINZA® when the next INVEGA SUSTENNA® dose is scheduled with an INVEGA TRINZA® dose based on the previousINVEGA SUSTENNA® dose, using the equivalent 3.5-fold higher dose as shown in table below.
INVEGA TRINZA® Doses for Adult Patients Adequately Treated with INVEGA SUSTENNA®
| If the Last Dose of INVEGA SUSTENNA® is: | Initiate INVEGA TRINZA® at the Following Dose: |
| 78 mg | 273 mg |
| 117 mg | 410 mg |
| 156 mg | 546 mg |
| 234 mg | 819 mg |
Conversion from the INVEGA SUSTENNA® 39 mg dose was not studied.
- Administration: For intramuscular injection only by a healthcare professional. Care should be taken to avoid inadvertent injection into a blood vessel.
INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]
INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]