INVEGA TRINZA® Common Dosing and Administration Topics

Switching

From INVEGA TRINZA® to Oral INVEGA® ER

Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA®:

  • INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® has been established as adequate treatment for at least four months.
  • For switching from INVEGA TRINZA® to INVEGA®, the daily dosing of the INVEGA® should be started 3 months after the last INVEGA TRINZA® dose and transitioned over the next several months following the last INVEGA TRINZA® dose as described in the table below. The table provides dose conversion regimens to allow patients previously stabilized on different doses of INVEGA TRINZA® to attain similar paliperidone exposure with INVEGA®.

INVEGA TRINZA® Doses and INVEGA® Conversion Regimens Needed to Attain Similar Paliperidone Exposures

Weeks Since Last INVEGA TRINZA® Dose

3 months to 18 weeks

Longer than 18 weeks to 24 weeks

Longer than 24 weeks

Last INVEGA TRINZA® Dose

Doses of INVEGA®

273 mg

3 mg

3 mg

3 mg

410 mg

3 mg

3 mg

6 mg

546 mg

3 mg

6 mg

9 mg

819 mg

6 mg

9 mg

12 mg

For illustrative displays of this dosing scenario, please click the links below.

Educational Dose Illustrator for:
INVEGA SUSTENNA® (paliperidone palmitate)
INVEGA TRINZA® (paliperidone palmitate)

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

  • the treatment of schizophrenia in adults
  • the treatment of schizoaffective disorder in adults as monotherapy and as an adjunct to mood stabilizers or antidepressants

INVEGA TRINZA® for:

  • the treatment of schizophrenia in patients after they have been adequately treated with INVEGA SUSTENNA® for at least four months.

This resource simulates the paliperidone plasma concentrations over time resulting from different dosing scenarios that are set forth in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. The Educational Dose Illustrator is intended to be used as a resource to foster a better understanding of, and educate healthcare professionals about, the dosing recommendations provided in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. It is intended for educational purposes only.

Because the simulated patient paliperidone plasma levels shown in the dosing scenarios are based upon aggregated pharmacokinetic information from clinical studies, the simulations may not be representative of individual patient response.

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