Educational Dose Illustrator

INVEGA TRINZA® (paliperidone palmitate) For Schizophrenia

See Important Safety Information throughout this document.

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

INVEGA TRINZA® for:

View this website online by scanning the QR code or visiting the URL below http://www.EducationalDoseIllustrator.com

Switching to INVEGA SUSTENNA® After 4th Dose of INVEGA TRINZA®

Graph

Key

  1. Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA SUSTENNA®:

    • In this illustrative example, after four doses of INVEGA TRINZA® were administered (last injection at week 57), a decision was made to switch back to INVEGA SUSTENNA® treatment. INVEGA SUSTENNA® should be started 3 months after the last INVEGA TRINZA® dose, using the equivalent 3.5-fold lower dose as shown in the table below.

    Conversion From INVEGA TRINZA® to INVEGA SUSTENNA®

    If the Last Dose of
    INVEGA TRINZA® is:

    Initiate* INVEGA SUSTENNA®
    3 Months Later at the Following Dose:

    273 mg

    78 mg

    410 mg

    117 mg

    546 mg

    156 mg

    819 mg

    234 mg

    * The initiation dosing as described in the prescribing information for INVEGA SUSTENNA® is not required.

    INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

  2. Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA SUSTENNA®:

    • INVEGA SUSTENNA® (1-month paliperidone palmitate extended-release injectable suspension) should then continue, dosed at monthly intervals.

    INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]
Dose Information

Graph Information

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INVEGA TRINZA® Switching to INVEGA SUSTENNA®

Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA SUSTENNA®:

Conversion From INVEGA TRINZA® to INVEGA SUSTENNA®

If the Last Dose of INVEGA TRINZA® is: Initiate* INVEGA SUSTENNA® 3 Months Later at the Following Dose:
273 mg
78 mg
410 mg
117 mg
546 mg
156 mg
819 mg
234 mg
* The initiation dosing as described in the prescribing information for INVEGA SUSTENNA® is not required.

INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

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