Educational Dose Illustrator

INVEGA SUSTENNA® For Schizophrenia

See Important Safety Information throughout this document.

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

INVEGA TRINZA® for:

View this website online by scanning the QR code or visiting the URL below http://www.EducationalDoseIllustrator.com

Standard Dosing

Graph

Key

  1. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    The release of the drug from a single dose of paliperidone palmitate starts as early as day 1 and lasts for as long as 126 days. Paliperidone plasma levels from INVEGA SUSTENNA® begin to overlap with the exposure range observed with oral INVEGA® ER 6-12 mg.

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

    INVEGA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA-pi.pdf]

  2. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    The second initiation dose of INVEGA SUSTENNA® 156 mg IM in the deltoid muscle one week later is necessary to help attain therapeutic concentrations rapidly.

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

  3. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    Overall initiation plasma levels with INVEGA SUSTENNA® are within the exposure range observed with 6-12 mg oral INVEGA® ER. The use of the INVEGA SUSTENNA® initiation regimen allows patients to stay in this exposure window even on trough pre-dose times (Week 1 and Week 5).

    The first maintenance dose is administered one month after the second initiation dose (Week 5).

    The INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf] recommends a monthly maintenance dose for schizophrenia of 117 mg. Some patients may benefit from lower or higher maintenance doses within the additional available strengths (39 mg, 78 mg, 156 mg, and 234 mg).

    Monthly maintenance doses can be administered in either the deltoid or gluteal muscle.

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

    INVEGA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA-pi.pdf]

Dose Information

Graph Information

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INVEGA SUSTENNA® Standard Dosing

Consistent with the INVEGA SUSTENNA® Prescribing Information:

Initiation Dosing:

Maintenance Dosing:

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

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