Educational Dose Illustrator

INVEGA SUSTENNA® For Schizophrenia

See Important Safety Information throughout this document.

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

INVEGA TRINZA® for:

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Dosing in Mild Renal Impairment

Graph

Key

  1. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    INVEGA SUSTENNA® has not been systematically studied in patients with renal impairment. Based on a limited number of observations with INVEGA SUSTENNA® in subjects with mild renal impairment and pharmacokinetic simulations, the dose of INVEGA SUSTENNA® should be reduced in patients with mild renal impairment; INVEGA SUSTENNA® is not recommended in patients with moderate or severe renal impairment.

    For patients with mild renal impairment [creatinine clearance ≥ 50 mL/min to < 80 mL/min (Cockcroft-Gault Formula)], initiate INVEGA SUSTENNA® with a dose of 156 mg followed by 117 mg one week later. Administer both doses in the deltoid muscle. Thereafter, follow with monthly injections of 78 mg in either the deltoid or gluteal muscle, which can be adjusted within the range of 39 mg to 156 mg based on tolerability and/or efficacy.

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

Dose Information

Graph Information

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INVEGA SUSTENNA® Dosing in Mild Renal Impairment

Consistent with the INVEGA SUSTENNA® Prescribing Information:

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

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