Educational Dose Illustrator

INVEGA SUSTENNA® For Schizophrenia

See Important Safety Information throughout this document.

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

INVEGA TRINZA® for:

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Missed 2nd Initiation Dose: <4 Weeks Since 1st injection

Graph

Key

  1. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    The release of the drug from a single dose of paliperidone palmitate starts as early as day 1 and lasts for as long as 126 days with the 234 mg dose. However, a second dose of INVEGA SUSTENNA® 156 mg administered in the deltoid one week later is necessary to attain therapeutic concentrations rapidly.

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

  2. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    If less than 4 weeks since the 1st injection of INVEGA SUSTENNA®, administer a second injection of 156 mg in the deltoid muscle as soon as possible.

    Please see the example below.

    EXAMPLE USING THE INVEGA SUSTENNA® PRESCRIBING INFORMATION: The second initiation dose of INVEGA SUSTENNA® was administered on Day 21. The second initiation dose may be dragged anywhere from Day 13 – Day 28 on the timeline, as this would be considered a missed dose beyond the ±4 day flexible initiation dosing window.

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

  3. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    It is recommended to administer a third injection of INVEGA SUSTENNA® 117 mg in either the deltoid or gluteal muscle 5 weeks after the first injection (regardless of the timing of the second injection). Thereafter, resume regular monthly dosing in either the deltoid or gluteal muscle.

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

Dose Information

Graph Information

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INVEGA SUSTENNA® 2nd Initiation Dose: <4 weeks since 1st injection

Consistent with the INVEGA SUSTENNA® Prescribing Information:

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

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