Educational Dose Illustrator

INVEGA SUSTENNA® For Schizoaffective Disorder

See Important Safety Information throughout this document.

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

INVEGA TRINZA® for:

View this website online by scanning the QR code or visiting the URL below http://www.EducationalDoseIllustrator.com

Maintenance Dose Adjustment

Graph

Key

  1. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    The first maintenance dose is administered 5 weeks after the first initiation dose (Week 5) regardless of the timing of the second initiation dose.

    The INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf] recommends adjustment of the monthly maintenance dose for schizoaffective disorder based on tolerability and/or efficacy using available strengths. The 39 mg strength was not studied in the long-term schizoaffective disorder study.

    For subjects randomized to INVEGA SUSTENNA® in the long-term schizoaffective disorder study, the distribution of monthly maintenance doses was 78 mg (4.9%), 117 mg (9.8%), 156 mg (47.0%), and 234 mg (38.4%).

    Monthly maintenance doses can be administered in either the deltoid or gluteal muscle.

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

  2. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    The median half-life of paliperidone following single doses of INVEGA SUSTENNA® ranges from 25-49 days, depending on the dosage strength. Therefore, the full effect of this dose adjustment may not be evident for several months due to the prolonged-release characteristics of this formulation. Steady-state is generally thought to occur after approximately 5 half-lives.

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

Dose Information

Graph Information

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INVEGA SUSTENNA® Maintenance Dose Adjustment

Consistent with the INVEGA SUSTENNA® Prescribing Information:

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

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