Educational Dose Illustrator

INVEGA TRINZA® (paliperidone palmitate) For Schizophrenia

See Important Safety Information throughout this document.

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

INVEGA TRINZA® for:

View this website online by scanning the QR code or visiting the URL below http://www.EducationalDoseIllustrator.com

Switching to Oral INVEGA® ER after 4th INVEGA TRINZA® injection

Graph

Key

  1. Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA®:

    • In this illustrative example, after four doses of INVEGA TRINZA® were administered, a decision was made to switch to daily INVEGA®.
    • Daily dosing of INVEGA® should be started 3 months after the last INVEGA TRINZA® dose and transitioned over the next several months following the last INVEGA TRINZA® dose as described in the table below.
    • The table provides dose conversion regimens to allow patients previously stabilized on different doses of INVEGA TRINZA® to attain similar paliperidone exposure with INVEGA®.

    INVEGA TRINZA® Doses and INVEGA® Conversion Regimens Needed to Attain Similar Paliperidone Exposures

    Weeks Since Last INVEGA TRINZA® Dose

    3 months to 18 weeks

    Longer than 18 weeks

    to 24 weeks

    Longer than 24 weeks

    Last INVEGA TRINZA® Dose

    Doses of INVEGA®

    273 mg

    3 mg

    3 mg

    3 mg

    410 mg

    3 mg

    3 mg

    6 mg

    546 mg

    3 mg

    6 mg

    9 mg

    819 mg

    6 mg

    9 mg

    12 mg

    INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

    INVEGA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA-pi.pdf]

Dose Information

Graph Information

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INVEGA TRINZA® Switching to Oral INVEGA®

Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA®:

INVEGA TRINZA® Doses and INVEGA® Conversion Regimens Needed to Attain Similar Paliperidone Exposures

Weeks Since Last INVEGA TRINZA® Dose

3 months to 18 weeks

Longer than 18 weeks

to 24 weeks

Longer than 24 weeks

Last INVEGA TRINZA® Dose

Doses of INVEGA®

273 mg

3 mg

3 mg

3 mg

410 mg

3 mg

3 mg

6 mg

546 mg

3 mg

6 mg

9 mg

819 mg

6 mg

9 mg

12 mg

INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

INVEGA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA-pi.pdf]

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