Educational Dose Illustrator

INVEGA TRINZA® (paliperidone palmitate) For Schizophrenia

See Important Safety Information throughout this document.

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

INVEGA TRINZA® for:

View this website online by scanning the QR code or visiting the URL below http://www.EducationalDoseIllustrator.com

Mild Renal Impairment

Graph

Key

  1. Consistent with the INVEGA TRINZA® Prescribing Information:

    • INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® has been established as adequate treatment for at least four months.
    • In order to establish a consistent maintenance dose, it is recommended that the last two doses of INVEGA SUSTENNA® be the same dosage strength before starting INVEGA TRINZA®.
    • For patients with mild renal impairment (creatinine clearance ≥50 mL/min to <80 mL/min [Cockcroft-Gault Formula], adjust dosage and stabilize the patient using INVEGA SUSTENNA®, then transition to INVEGA TRINZA®.
    • INVEGA TRINZA® is not recommended in patients with moderate or severe renal impairment (creatinine clearance <50 mL/min).

    INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

  2. Consistent with the INVEGA TRINZA® Prescribing Information:

    • Transition to INVEGA TRINZA® using the equivalent 3.5-fold higher dose as shown in the table below.

    INVEGA TRINZA® Doses for Adult Patients Adequately Treated with INVEGA SUSTENNA®

    If the Last Dose of INVEGA SUSTENNA® is:

    Initiate INVEGA TRINZA® at the Following Dose:

    78 mg

    273 mg

    117 mg

    410 mg

    156 mg

    546 mg

    234 mg

    819 mg

    Conversion from the INVEGA SUSTENNA® 39 mg dose was not studied.

    • INVEGA TRINZA® should be administered every 3 months.
    • Administration: For intramuscular injection only by a healthcare professional. Care should be taken to avoid inadvertent injection into a blood vessel.

    INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

Dose Information

Graph Information

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Transitioning a Patient with Mild Renal Impairment to INVEGA TRINZA®

Consistent with the INVEGA TRINZA® Prescribing Information:

INVEGA TRINZA® Doses for Adult Patients Adequately Treated with INVEGA SUSTENNA®

If the Last Dose of INVEGA SUSTENNA® is:

Initiate INVEGA TRINZA® at the Following Dose:

78 mg

273 mg

117 mg

410 mg

156 mg

546 mg

234 mg

819 mg

Conversion from the INVEGA SUSTENNA® 39 mg dose was not studied.

INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

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