5th injection 15 Weeks Since 4th INVEGA TRINZA® Injection
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Legend
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Initiation Doses
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Maintenance Doses
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Cumulative INVEGA SUSTENNA® Plasma Concentration
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Cumulative INVEGA TRINZA® Plasma Concentration
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Cumulative Oral INVEGA® ER Plasma Concentration
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Daily Oral INVEGA® Doses
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Cumulative RISPERDAL CONSTA® Plasma Concentration
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Median Plasma Concentration for Oral INVEGA® ER 6-12 mg/day
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Initiation Doses
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Maintenance Doses
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Cumulative Paliperidone Palmitate Concentration
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Daily Oral INVEGA® ER Dose
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Cumulative RISPERDAL CONSTA® Plasma Concentration
Week 1 = Day 8
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Dose Information |
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The dosage strength (234 mg) and dosage location (deltoid muscle) of the first INVEGA SUSTENNA® initiation dose is fixed per the INVEGA SUSTENNA® Prescribing Information. Dosage Timing: The first INVEGA SUSTENNA® initiation dose occurs on Day 1 (on the x-axis). |
The dosage strength (156 mg) and dosage location (deltoid muscle) of the second INVEGA SUSTENNA® initiation dose is fixed per the INVEGA SUSTENNA® Prescribing Information. Dosage Timing: While the INVEGA SUSTENNA® Prescribing Information does permit a dosing window of ±4 days to help avoid a missed second initiation dose, for illustrative purposes, the timing of the second INVEGA SUSTENNA® dose cannot be adjusted. |
Dosage Strength: The recommended maintenance dosage strength for the treatment of schizophrenia is 117 mg per the INVEGA SUSTENNA® Prescribing Information. Some patients may benefit from lower or higher maintenance doses within the additional available strengths (39 mg, 78 mg, 156 mg, and 234 mg). Dosage Location: The INVEGA SUSTENNA® monthly maintenance doses can be administered in either the deltoid or gluteal muscle per the INVEGA SUSTENNA® Prescribing Information. For illustrative purposes only, once you select the deltoid or gluteal muscle for an INVEGA SUSTENNA® maintenance dose, the site of injection will remain constant for all remaining INVEGA SUSTENNA® maintenance doses. Dosage Timing: While the INVEGA SUSTENNA® Prescribing Information does permit a dosing window of ±7 days to help avoid a missed monthly dose, for illustrative purposes, the timing of the INVEGA SUSTENNA® maintenance doses cannot be adjusted. |
Dosage Strength: For illustrative purposes only, the INVEGA SUSTENNA® maintenance dosage strength may be adjusted by one dose increment up or down from the previous dose administered. Dosage Location: For illustrative purposes only, once you select the deltoid or gluteal muscle for an INVEGA SUSTENNA® maintenance dose, the site of injection will remain constant for all remaining INVEGA SUSTENNA® maintenance doses. Dosage Timing: While the INVEGA SUSTENNA® Prescribing Information does permit a dosing window of ±7 days to help avoid a missed monthly dose, for illustrative purposes, the timing of the INVEGA SUSTENNA® maintenance doses cannot be adjusted. |
Dosage Strength: For illustrative purposes only, the INVEGA SUSTENNA® maintenance dosage strength may be adjusted by one dose increment up or down from the previous dose administered. Dosage Location: For illustrative purposes only, once you select the deltoid or gluteal muscle for an INVEGA SUSTENNA® maintenance dose, the site of injection will remain constant for all remaining INVEGA SUSTENNA® maintenance doses. Dosage Timing: While the INVEGA SUSTENNA® Prescribing Information does permit a dosing window of ±7 days to help avoid a missed monthly dose, for illustrative purposes, the timing of the INVEGA SUSTENNA® maintenance doses cannot be adjusted. |
Dosage Strength: The last two doses of INVEGA SUSTENNA® must be the same dosage strength in order to establish a consistent maintenance dose before starting INVEGA TRINZA®, as recommended per the INVEGA TRINZA® Prescribing Information. Dosage Location: For illustrative purposes only, once you select the deltoid or gluteal muscle for an INVEGA SUSTENNA® maintenance dose, the site of injection will remain constant for all remaining INVEGA SUSTENNA® maintenance doses. Dosage Timing: While the INVEGA SUSTENNA® Prescribing Information does permit a dosing window of ±7 days to help avoid a missed monthly dose, for illustrative purposes, the timing of the INVEGA SUSTENNA® maintenance doses cannot be adjusted. |
Dosage Strength: The first INVEGA TRINZA® dose is determined by the consistent INVEGA SUSTENNA® maintenance dose, using the equivalent 3.5-fold higher INVEGA TRINZA® dosage strength per the INVEGA TRINZA® Prescribing Information. Adjustment to the final INVEGA SUSTENNA® maintenance doses will adjust all INVEGA TRINZA® dosage strengths. Dosage Location: The INVEGA TRINZA® dose can be administered in either the deltoid or gluteal muscle per the INVEGA TRINZA® Prescribing Information. Dosage Timing: For illustrative purposes only, the timing of the first INVEGA TRINZA® dose cannot be adjusted. However, the INVEGA TRINZA® Prescribing Information does allow the first INVEGA TRINZA® dose to be administered ±7 days of the next scheduled INVEGA SUSTENNA® dose. |
Dosage Strength: For illustrative purposes only, the INVEGA TRINZA® maintenance dosage strength will remain constant for all INVEGA TRINZA® maintenance doses. INVEGA TRINZA® dosage adjustments can be made every 3 months in increments within the range of 273 mg to 819 mg based on individual patient tolerability and/or efficacy per the INVEGA TRINZA® Prescribing Information. Dosage Location: For illustrative purposes only, once you select the deltoid or gluteal muscle for an INVEGA TRINZA® maintenance dose, the site of injection will remain constant for all remaining INVEGA TRINZA® maintenance doses. Dosage Timing: While the INVEGA TRINZA® Prescribing Information does permit a dosing window of ±2 weeks to help avoid a missed dose, for illustrative purposes, the timing of the INVEGA TRINZA® maintenance dose cannot be adjusted. |
Dosage Strength: For illustrative purposes only, the INVEGA TRINZA® maintenance dosage strength will remain constant for all INVEGA TRINZA® maintenance doses. INVEGA TRINZA® dosage adjustments can be made every 3 months in increments within the range of 273 mg to 819 mg based on individual patient tolerability and/or efficacy per the INVEGA TRINZA® Prescribing Information. Dosage Location: For illustrative purposes only, once you select the deltoid or gluteal muscle for an INVEGA TRINZA® maintenance dose, the site of injection will remain constant for all remaining INVEGA TRINZA® maintenance doses. Dosage Timing: While the INVEGA TRINZA® Prescribing Information does permit a dosing window of ±2 weeks to help avoid a missed dose, for illustrative purposes, the timing of the INVEGA TRINZA® maintenance dose cannot be adjusted. |
Dosage Strength: For illustrative purposes only, the INVEGA TRINZA® maintenance dosage strength will remain constant for all INVEGA TRINZA® maintenance doses. INVEGA TRINZA® dosage adjustments can be made every 3 months in increments within the range of 273 mg to 819 mg based on individual patient tolerability and/or efficacy per the INVEGA TRINZA® Prescribing Information. Dosage Location: For illustrative purposes only, once you select the deltoid or gluteal muscle for an INVEGA TRINZA® maintenance dose, the site of injection will remain constant for all remaining INVEGA TRINZA® maintenance doses. Dosage Timing: While the INVEGA TRINZA® Prescribing Information does permit a dosing window of ±2 weeks to help avoid a missed dose, for illustrative purposes, the timing of the INVEGA TRINZA® maintenance dose cannot be adjusted. |
Dosage Strength: For illustrative purposes only, the INVEGA TRINZA® maintenance dosage strength will remain constant for all INVEGA TRINZA® maintenance doses. INVEGA TRINZA® dosage adjustments can be made every 3 months in increments within the range of 273 mg to 819 mg based on individual patient tolerability and/or efficacy per the INVEGA TRINZA® Prescribing Information. Dosage Location: For illustrative purposes only, once you select the deltoid or gluteal muscle for an INVEGA TRINZA® maintenance dose, the site of injection will remain constant for all remaining INVEGA TRINZA® maintenance doses. Dosage Timing: While the INVEGA TRINZA® Prescribing Information does permit a dosing window of ±2 weeks to help avoid a missed dose, for illustrative purposes, the timing of the INVEGA TRINZA® maintenance dose cannot be adjusted. |
Dosage Strength: For illustrative purposes only, the INVEGA TRINZA® maintenance dosage strength will remain constant for all INVEGA TRINZA® maintenance doses. INVEGA TRINZA® dosage adjustments can be made every 3 months in increments within the range of 273 mg to 819 mg based on individual patient tolerability and/or efficacy per the INVEGA TRINZA® Prescribing Information. Dosage Location: For illustrative purposes only, once you select the deltoid or gluteal muscle for an INVEGA TRINZA® maintenance dose, the site of injection will remain constant for all remaining INVEGA TRINZA® maintenance doses. Dosage Timing: While the INVEGA TRINZA® Prescribing Information does permit a dosing window of ±2 weeks to help avoid a missed dose, for illustrative purposes, the timing of the INVEGA TRINZA® maintenance dose cannot be adjusted. |
Graph Information
INVEGA TRINZA® Managing a Missed Dose (3½ to Less than 4 Months since the last injection)
Consistent with the INVEGA TRINZA® Prescribing Information:
- INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® has been established as adequate treatment for at least four months.
- INVEGA TRINZA® should be administered every 3 months.
- Missing doses of INVEGA TRINZA® should be avoided.
- Administration: For intramuscular injection only by a healthcare professional. Care should be taken to avoid inadvertent injection into a blood vessel.
INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]