Educational Dose Illustrator

INVEGA TRINZA® (paliperidone palmitate) For Schizophrenia

See Important Safety Information throughout this document.

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

INVEGA TRINZA® for:

View this website online by scanning the QR code or visiting the URL below http://www.EducationalDoseIllustrator.com

3rd Injection 37 Weeks Since 2nd Injection

Graph

Key

  1. Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA SUSTENNA®:

    • Missing doses of INVEGA TRINZA® should be avoided.
    • In this illustrative example, the third INVEGA TRINZA® dose was missed at Week 45. Since more than 9 months have elapsed since the last INVEGA TRINZA® injection, treatment was reinitiated at Week 70 with an INVEGA SUSTENNA® 234 mg injection followed an INVEGA SUSTENNA® 156 mg injection one week later (both administered in the deltoid muscle).

    INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

  2. Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA SUSTENNA®:

    Following the re-initiation of INVEGA SUSTENNA® treatment, monthly maintenance doses can be administered in either the deltoid or gluteal muscle.

    In this illustrative example, four INVEGA SUSTENNA® monthly maintenance doses are administered using the same dosage strengths and injection site locations used to initially begin treatment with INVEGA SUSTENNA®.

    INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

  3. Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA SUSTENNA®:

    • INVEGA TRINZA® can then be resumed after the patient has been adequately treated with INVEGA SUSTENNA® for at least 4 months.
    • In this illustrative example, INVEGA TRINZA® resumed when the next INVEGA SUSTENNA® dose was scheduled with an INVEGA TRINZA® dose based on the previous INVEGA SUSTENNA® dose, using the equivalent 3.5-fold higher dose as shown in the table below.

    INVEGA TRINZA® Doses for Adult Patients Adequately Treated with INVEGA SUSTENNA®

    If the Last Dose of INVEGA SUSTENNA® is:

    Initiate INVEGA TRINZA® at the Following Dose:

    78 mg

    273 mg

    117 mg

    410 mg

    156 mg

    546 mg

    234 mg

    819 mg

    Conversion from the INVEGA SUSTENNA® 39 mg dose was not studied.

    • INVEGA TRINZA® should be administered every 3 months

    INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

Dose Information

Graph Information

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INVEGA TRINZA® Managing a Missed Dose (>9 months since the last injection)

Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA SUSTENNA®:

INVEGA TRINZA® Doses for Adult Patients Adequately Treated with INVEGA SUSTENNA®

If the Last Dose of INVEGA SUSTENNA® is:

Initiate INVEGA TRINZA® at the Following Dose:

78 mg

273 mg

117 mg

410 mg

156 mg

546 mg

234 mg

819 mg

Conversion from the INVEGA SUSTENNA® 39 mg dose was not studied.

INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

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