INVEGA TRINZA® Common Dosing and Administration Topics

Administration

Overview

Consistent with the INVEGA TRINZA® Prescribing Information:

  • INVEGA TRINZA® should be administered once every 3 months. Each injection must be administered only by a health care professional.
  • Parenteral drug products should be inspected visually for foreign matter and discoloration prior to administration.
  • It is important to shake the syringe vigorously for at least 15 seconds to ensure a homogeneous suspension. Inject INVEGA TRINZA® within 5 minutes of shaking vigorously.
  • INVEGA TRINZA® is intended for intramuscular use only. Do not administer by any other route. Avoid inadvertent injection into a blood vessel. Administer the dose in a single injection; do not administer the dose in divided injections. Inject slowly, deep into the deltoid or gluteal muscle.
  • INVEGA TRINZA® must be administered using only the thin wall needles that are provided in the INVEGA TRINZA® pack. Do not use needles from the INVEGA SUSTENNA® pack or other commercially-available needles to reduce the risk of blockage.
  • Deltoid Injection - The recommended needle size for administration of INVEGA TRINZA® into the deltoid muscle is determined by the patient’s weight:
    • For patients weighing less than 90 kg, the 1-inch, 22 gauge thin wall needle is recommended.
    • For patients weighing 90 kg or more, the 1½-inch, 22 gauge thin wall needle is recommended.
  • Administer into the center of the deltoid muscle. Deltoid injections should be alternated between the two deltoid muscles.
  • Gluteal Injection - Regardless of patient weight, the recommended needle size for administration of INVEGA TRINZA® into the gluteal muscle is the 1½-inch, 22 gauge thin wall needle. Administer into the upper-outer quadrant of the gluteal muscle. Gluteal injections should be alternated between the two gluteal muscles.
  • Incomplete Administration - To avoid an incomplete administration of INVEGA TRINZA®, ensure that the prefilled syringe is shaken vigorously for at least 15 seconds within 5 minutes prior to administration to ensure a homogeneous suspension and ensure the needle does not get clogged during injection. However, in the event of an incompletely administered dose, do not re-inject the dose remaining in the syringe and do not administer another dose of INVEGA TRINZA®. Closely monitor and treat the patient with oral supplementation as clinically appropriate until the next scheduled injection of INVEGA TRINZA®.

Educational Dose Illustrator for:
INVEGA SUSTENNA® (paliperidone palmitate)
INVEGA TRINZA® (paliperidone palmitate)

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

  • the treatment of schizophrenia in adults
  • the treatment of schizoaffective disorder in adults as monotherapy and as an adjunct to mood stabilizers or antidepressants

INVEGA TRINZA® for:

  • the treatment of schizophrenia in patients after they have been adequately treated with INVEGA SUSTENNA® for at least four months.

This resource simulates the paliperidone plasma concentrations over time resulting from different dosing scenarios that are set forth in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. The Educational Dose Illustrator is intended to be used as a resource to foster a better understanding of, and educate healthcare professionals about, the dosing recommendations provided in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. It is intended for educational purposes only.

Because the simulated patient paliperidone plasma levels shown in the dosing scenarios are based upon aggregated pharmacokinetic information from clinical studies, the simulations may not be representative of individual patient response.

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