Educational Dose Illustrator

INVEGA SUSTENNA® For Schizophrenia

See Important Safety Information throughout this document.

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

INVEGA TRINZA® for:

View this website online by scanning the QR code or visiting the URL below http://www.EducationalDoseIllustrator.com

Initiation Dosing

Graph

Key

  1. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    The release of the drug from a single dose of paliperidone palmitate starts as early as day 1 and lasts for as long as 126 days. Paliperidone plasma levels from INVEGA SUSTENNA® begin to overlap with the exposure range observed with oral INVEGA® ER 6-12 mg.

    The second initiation dose of INVEGA SUSTENNA® 156 mg IM in the deltoid muscle one week later is necessary to help attain therapeutic concentrations rapidly.

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

    INVEGA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA-pi.pdf]

  2. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    Overall initiation plasma levels with INVEGA SUSTENNA® were within the exposure range observed with 6-12 mg oral INVEGA® ER. The use of INVEGA SUSTENNA® initiation regimen allows patients to stay in this exposure window even at trough pre-dose times (Week 1 and Week 5).

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

    INVEGA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA-pi.pdf]

Dose Information

Graph Information

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INVEGA SUSTENNA® Initiation Dosing

Consistent with the INVEGA SUSTENNA® Prescribing Information:

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

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