INVEGA SUSTENNA® Common Dosing and Administration Topics
Switching from Other Antipsychotics
From Oral INVEGA® ER to INVEGA SUSTENNA® – General Overview
Consistent with the INVEGA SUSTENNA® Prescribing Information:
- There are no systematically collected data to specifically address switching patients with schizophrenia or schizoaffective disorder from other antipsychotics to INVEGA SUSTENNA®, or concerning concomitant administration with other antipsychotics.
- Previous oral antipsychotics can be gradually discontinued at the time of initiation of treatment with INVEGA SUSTENNA®. Recommended initiation of INVEGA SUSTENNA® is with a dose of 234 mg followed by 156 mg one week later, both administered in the deltoid muscle. Patients previously stabilized on different doses of oral INVEGA® ER can attain similar paliperidone steady-state exposure during maintenance treatment with INVEGA SUSTENNA® monthly doses as depicted in the Table from the INVEGA SUSTENNA® Prescribing Information.
Table: Doses of INVEGA® and INVEGA SUSTENNA® needed to attain similar steady-state palliperidone exposure during maintenance treatment
|Formulation||INVEGA® Exteneded-Release Tablet||INVEGA SUSTENNA® Injection|
|Dosing Frequency||Once Daily||Once every 4 weeks|
For illustrative displays of this dosing scenario, please click the link(s) below.