Missed Maintenance Dose: >6 Weeks to 6 Months Since Last Injection

  • Legend
    • legend-oier-dose-symbol

      Cumulative Paliperidone Plasma Concentration from INVEGA® ER

    • legend-or-dose-symbol

      Cumulative active moiety concentration of risperidone + 9-OH-risperidone (paliperidone) from RISPERDAL

    • initiation-dosing-symbol

      Initiation Dosing

    • maintenace-dose-symbol

      Maintenance Doses

    • cumulative-paliperidone-plasma-concentration-symbol

      Cumulative Paliperidone Plasma Concentration

    • individual-dose-curves-symbol

      Individual Dose Curves

    • median-plasma-concentration-symbol

      Median Plasma Concentration for Oral INVEGA® ER 6-12 mg/day

    • Week 1 = Day 8

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Typical Paliperidone Plasma Concentration (ng/mL)
Typical Paliperidone Plasma Concentration (ng/mL)
Dose Information

Graph Information

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INVEGA SUSTENNA® Missed Maintenance Dose: > 6 Weeks to 6 Months Since Last Injection

Consistent with the INVEGA SUSTENNA® Prescribing Information:

  • After the first two initiation doses, the recommended maintenance injection cycle is monthly.
    TIMING OF MISSED MAINTENANCE DOSE DOSING
    More than 6 weeks to 6 months since last injection Resume the same dose the patient was previously stabilized on (unless the patient was stabilized on a dose of 234 mg, then the first 2 injections should each be 156 mg) in the following manner:
    1. Administer a deltoid injection as soon as possible.
    2. Administer a second deltoid injection 1 week later at the same dose.
    3. Thereafter, resume administering the previously stabilized dose in the deltoid or gluteal muscle 1 month after the second injection.
  • Administration: Each injection must be administered only by a healthcare professional. INVEGA SUSTENNA® is intended for intramuscular use only. Do not administer by any other route. Avoid inadvertent injection into a blood vessel.

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

Educational Dose Illustrator for:
INVEGA SUSTENNA® (paliperidone palmitate)
INVEGA TRINZA® (paliperidone palmitate)

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

  • the treatment of schizophrenia in adults
  • the treatment of schizoaffective disorder in adults as monotherapy and as an adjunct to mood stabilizers or antidepressants

INVEGA TRINZA® for:

  • the treatment of schizophrenia in patients after they have been adequately treated with INVEGA SUSTENNA® for at least four months.

This resource simulates the paliperidone plasma concentrations over time resulting from different dosing scenarios that are set forth in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. The Educational Dose Illustrator is intended to be used as a resource to foster a better understanding of, and educate healthcare professionals about, the dosing recommendations provided in the respective Prescribing Information for INVEGA SUSTENNA® and INVEGA TRINZA®. It is intended for educational purposes only.

Because the simulated patient paliperidone plasma levels shown in the dosing scenarios are based upon aggregated pharmacokinetic information from clinical studies, the simulations may not be representative of individual patient response.

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