Educational Dose Illustrator

INVEGA SUSTENNA® For Schizoaffective Disorder

See Important Safety Information throughout this document.

The Educational Dose Illustrator can be used to visualize how dosing affects paliperidone plasma concentrations following administration of:

INVEGA SUSTENNA® for:

INVEGA TRINZA® for:

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Missed 2nd Initiation Dose: 4-7 Weeks Since 1st injection

Graph

Key

  1. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    If 4 to 7 weeks have elapsed since the first injection, resume dosing with two injections of 156 mg in the following manner: 1) administer a deltoid injection as soon as possible and 2) administer a second deltoid injection one week later. Thereafter, resume regular monthly dosing in either the deltoid or gluteal muscle.

    Please see the example below.

    EXAMPLE USING THE INVEGA SUSTENNA® PRESCRIBING INFORMATION: The second initiation dose of INVEGA SUSTENNA® was administered on Day 36 in the deltoid muscle. The second initiation dose of 156 mg may be dragged anywhere from Day 29 – Day 50 on the timeline, followed by a third dose of 156 mg one week later in the deltoid muscle. Normal monthly maintenance dosing should be followed thereafter.

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

  2. Consistent with the INVEGA SUSTENNA® Prescribing Information:

    The release of the drug from a single dose of paliperidone palmitate starts as early as day 1 and lasts for as long as 126 days with the 234 mg dose. However, a second dose of INVEGA SUSTENNA® 156 mg administered in the deltoid one week later is necessary to attain therapeutic concentrations rapidly.

    INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

Dose Information

Graph Information

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INVEGA SUSTENNA® 2nd Initiation Dose: 4-7 weeks since 1st injection

Consistent with the INVEGA SUSTENNA® Prescribing Information:

INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]

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